Fri Feb 04 2022

111 articles - From Saturday Jan 29 2022 to Friday Feb 04 2022

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Guidelines

Guidelines, position statements, white papers, etc…

Gastroenterology

AGA Clinical Practice Update on Approach to the Use of Noninvasive Colorectal Cancer Screening Options: Commentary.

This Clinical Practice Update was commissioned and approved by the AGA Institute Clinical Practice Updates Committee and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership, and underwent internal peer review by the Clinical Practice Updates Committee and external peer review through standard procedures of Gastroenterology. This expert commentary reflects recently published studies in this field, as well as the experiences of the authors who are gastroenterologists with high-level expertise in CRC screening and prevention.

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Meta-analysis

meta-analyses and systematic reviews

Aliment Pharmacol Ther

Systematic review with meta-analysis: artificial intelligence in the diagnosis of oesophageal diseases.

AI demonstrated high performance in the clinical and endoscopic diagnosis of OD.

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Endoscopy

Risk factors for gastric metachronous lesions after endoscopic or surgical resection: a systematic review and meta-analysis.

ER treatment was possible in 83.2% of 914 MGLs (95%CI 72.2 to 91.9%). CONCLUSION : Follow-up schedules should be different after ER and subtotal gastrectomy, and individualized further based on diverse risk factors.

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Studies

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Overt hepatic encephalopathy is an independent risk factor for de novo infection in cirrhotic patients with acute decompensation.

OHE is an independent risk factor for de novo infection in cirrhotic patients with AD.

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Am J Clin Nutr

An extract of hops (Humulus lupulus L.) modulates gut peptide hormone secretion and reduces energy intake in healthy-weight men: a randomized, cross-over clinical trial.

Both gastric and duodenal delivery of a hop extract modulates the release of hormones involved in appetite and glycemic regulation, providing a potential "bitter brake" on EI in healthy-weight men. Clinical Trial Registry ACTRN12614000434695 www.anzctr.org.au.

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Association of prolonged nightly fasting with cardiovascular, renal, inflammation, and nutritional status biomarkers in community-dwelling older adults.

Habitual prolonged nightly fasting did not show beneficial associations with the examined biomarkers. By contrast, some modest detrimental associations were found suggesting that extended periods of time between meals may not be beneficial for older adults. Clinical Trial Registry ClinicalTrials.gov NCT03541135.

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Body composition in ALS subjects and its effect on disease progression and survival.

Our equation broadens the traditional nutritional evaluation in clinics and reliably estimates body composition. Measuring body composition could target FM as a focus for nutritional management to ensure adequate energy intake and complement measures, such as the ALS functional rating scale-revised score and forced vital capacity, currently used.

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Combination of dynapenia and abdominal obesity affects long-term physical performance trajectories in older adults: Sex differences.

D/AO is associated with a stronger decline in physical performance in male but not female. The identification and management of dynapenic abdominal obesity may be essential to avoiding the first signs of functional impairment in older male.

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Diverging metabolic effects of two energy restricted diets differing in nutrient quality: a 12-week randomized controlled trial in subjects with abdominal obesity.

A high nutrient quality 25%ER diet is more beneficial for cardiometabolic health than a low nutrient quality 25%ER diet. Overweight insulin sensitive subjects may benefit more from a high than a low nutrient quality ER diet with respect to weight loss, due to potential attenuation of glucose-induced lipid synthesis in adipose tissue. Trial registration ClinicalTrials.gov NCT02194504.

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Effect of severe versus moderate energy restriction on physical activity among postmenopausal female adults with obesity: a pre-specified secondary analysis of the TEMPO Diet randomized controlled Trial.

Among female adults with obesity, including a dietary component to reduce excess body weight-notably one involving severe energy restriction-could potentially enhance the effectiveness of physical activity interventions.

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Fetal iron uptake from recent maternal diet and the maternal red blood cell iron pool.

Iron absorption doubled from T2 to T3 as maternal TBI declined. Women with low TBI had a greater decrease in RBC iron enrichment and transferred more RBC-derived iron to their neonate. These findings suggest maternal RBC iron serves as a significant source of iron for the fetus, particularly in women with depleted body iron stores. Clinical Trials This trial was registered at ClinicalTrials.gov as NCT01588665.

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Maternal anemia and preterm birth among women living with HIV in the United States.

Anemia is common in pregnant WLHIV, highlighting the need to address the underlying factors and clinical outcomes of anemia in this population.

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Vitamin D, D-binding protein, free vitamin D and COVID-19 mortality in hospitalized patients.

The frequency of vitamin D deficiency (25(OH)D 100nmol/L) levels may be associated with risk. Neither free nor bioavailable 25(OH) D associate with risk.

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Am J Gastroenterol

Antibody Response Three Months after Two-Dose SARS-CoV-2 mRNA Vaccination in patients with Inflammatory Bowel Disease.

Decreased antibody titers at 3 months was seen in a subset of patients on anti-TNF-a. About 10% of the participants with high titer antibodies at one month had a decrease to low positive titers at 3 months, which was mostly observed in those on combination therapy as well as anti-TNF-a monotherapy.

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Group cognitive behavioral therapy with interoceptive exposure for drug-refractory irritable bowel syndrome: a randomized controlled trial.

GCBT-IE is an efficacious, safe, and efficient treatment option for people with drug-refractory IBS.

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More endoscopy-based brushing passes improves the detection of malignant biliary strictures: a multicenter randomized controlled trial.

org. cn, identifier: ChiCTR1800015978).

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Relapse of HCV-Cryoglobulinemic Vasculitis Following Sustained Viral Response after Interferon-free Direct-Acting Antivirals.

A substantial proportion of CryoVas patients experience relapse after DAA-induced SVR. Relapses are moderate-to-severe, and impact survival after 24 months, mainly due to infections. Independent risk factors for relapse or death were found.

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Clin Gastroenterol Hepatol

Immunomodulator withdrawal from anti-TNF therapy is not associated with loss of response in inflammatory bowel disease.

Patients who withdrew the immunomodulator in this retrospective cohort were not at increased risk of LOR within the following 1-2 years, but an increase in anti-drug antibodies was observed. Our findings require prospective validation, preferably in adequately powered randomized-controlled trials.

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Inverse association between serum 25-hydroxyvitamin D and nonalcoholic fatty liver disease.

Our findings have clinical implications as they suggest that increased vitamin D levels may play a role in NAFLD prevention in European populations.

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Myosteatosis, but not sarcopenia, predisposes NAFLD subjects to early steatohepatitis and fibrosis progression.

Severe myosteatosis is significantly associated with early NASH and fibrosis progression in early-stage NAFLD.

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Endoscopy

Impact of Expert Center endoscopic assessment of confirmed LGD diagnosed in community hospitals.

One quarter of patients with apparent flat BE with confirmed LGD diagnosed in a community hospital turns out to have prevalent HGD or cancer after re-staging in an expert center. This endorses the advice to refer patients with confirmed LGD - also in the absence of visible lesions - to an expert center for re-staging endoscopy.

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Therapeutic endoscopic ultrasound: European Society of Gastrointestinal Endoscopy (ESGE) Technical Review.

8: ESGE recommends the use of either 15- or 20-mm LAMSs for EDGE, with a preference for 20-mm LAMSs when considering a same-session ERCP. Strong recommendation, low quality evidence.

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Gastroenterology

Disease Monitoring in IBD: evolving principles and possibilities.

We also discuss the importance of monitoring during key phases of the disease and propose an optimum treat to target monitoring strategy for Crohn's disease and ulcerative colitis. In the advent of new technology, we also discuss how this may improve our monitoring capabilities and how we envisage future monitoring strategies of inflammatory bowel diseases.

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WHAT DOES DISEASE PROGRESSION LOOK LIKE IN ULCERATIVE COLITIS AND HOW MIGHT IT BE PREVENTED?

This review summarizes the multiple facets of UC contributing to a modified perception of the disease as a progressive one. We propose further study of the natural history and priorities for further treatment goals that include these considerations.

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Gut

Tumour-associated neutrophils secrete AGR2 to promote colorectal cancer metastasis via its receptor CD98hc-xCT.

Our study unveils a novel crosstalk between TANs and CRC cells involving the secreted AGR2-CD98hc-xCT axis that promotes metastasis and impacts the outcomes of patients with CRC.

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Hepatology

Aspirin Use and Risk of Hepatocellular Carcinoma in Patients With Chronic Hepatitis B With or Without Cirrhosis.

Aspirin use was associated with reduced risks of HCC and liver-related mortality in adults with CHB. The cirrhosis status had a substantial effect on the association between aspirin use and HCC risk.

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Contrast-enhanced CT and liver surface nodularity for the diagnosis of porto-sinusoidal vascular disorder: a case-control study.

This study including a total of 103 patients with PSVD and 206 patients with cirrhosis demonstrates that LSN < 2.5 combined with normal-sized or enlarged segment IV strongly suggests PSVD in patients with signs of portal hypertension.

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Discovery of a INSIG binding compound that ameliorates nonalcoholic steatohepatitis by inhibiting SREBP-mediated lipogenesis.

This study provides the proof of concept that inhibiting SREBP activation by targeting INSIG to lower lipids could be a promising strategy for treating NASH. It suggests the translational potential of 25-HL in human NASH, and demonstrates the critical role of SREBP-controlled lipogenesis in the progression of NASH by pharmacological inhibition.

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KIAA1199 Drives Immune Suppression to Promote Colorectal Cancer Liver metastasis by Modulating Neutrophil Infiltration.

These findings indicated that KIAA1199 could facilitate the liver infiltration of immunosuppressive neutrophils via the TGFß-CXCL3/1-CXCR2 axis, which might be clinically targeted for the treatment of hepatic metastasis.

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PAK4 inhibition protects against liver ischemia/reperfusion injury: Role of Nrf2 phosphorylation.

PAK4 phosphorylates Nrf2 and suppresses its transcriptional activity. Genetic or pharmacological suppression of PAK4 alleviates hepatic I/R injury. Thus, PAK4 inhibition may represent a promising intervention against I/R induced liver injury.

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Sofosbuvir-Velpatasvir-Voxilaprevir in Adolescents 12 to 17 Years Old With Hepatitis C Virus Infection.

The pangenotypic regimen of sofosbuvir-velpatasvir-voxilaprevir is highly efficacious and well-tolerated in treating chronic HCV infection in adolescents.

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Tumor-Derived Exosomes Induce Immunosuppressive Macrophages to Foster Intrahepatic Cholangiocarcinoma Progression.

Tumor-derived exosomal miR-183-5p upregulates PD-L1 expressing macrophages to foster immune suppression and disease progression in ICC through miR-183-5p/PTEN/AKT/PD-L1 pathway. Exosomal miR-183-5p is a potential predictive biomarker for ICC progression, and a potential target for development of novel therapeutic strategies against immune tolerance feature of ICC.

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Inflamm Bowel Dis

Breastfeeding Patterns in Mothers with Inflammatory Bowel Disease: A Pilot Prospective Longitudinal Study.

Though most mothers with IBD initiate breastfeeding at time of delivery, about half continue beyond 6 months postpartum. Common reasons for this include perceived insufficient milk production and medication concerns. Larger studies are required to validate our findings in more generalizable settings such as primary and secondary care.

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Dietary Patterns and Their Association With Symptoms Activity in Inflammatory Bowel Diseases.

Diets with increased intake of fruits and vegetables, reduction of processed meats and refined carbohydrates, and preference of water for hydration were associated with lower risk of active symptoms with IBD, although increased intake of fruits and vegetables alone did not reduce risk of symptoms with CD.

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Geosocial Features and Loss of Biodiversity Underlie Variable Rates of Inflammatory Bowel Disease in a Large Developing Country: A Population-Based Study.

When distribution is considered in the context of IBD prevalence, marked regional differences become evident. Despite a background of Westernization, hotspots of IBD are recognized that are not explained by population density, urbanicity, sanitation, or other indices but apparently are explained by biodiversity loss. Thus, the rise of IBD in developing countries is not uniform, but rather is one that varies depending on yet unexplored factors like geoecological conditions.

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INSPECT: A Retrospective Study to Evaluate Long-term Effectiveness and Safety of Darvadstrocel in Patients With Perianal Fistulizing Crohn's Disease Treated in the ADMIRE-CD Trial.

Real-world follow-up of patients from the ADMIRE-CD trial indicates that clinical remission of complex perianal fistulas can be sustained in the long term irrespective of whether it is achieved through darvadstrocel administration or maintenance treatment regimens and confirms a favorable long-term safety profile of darvadstrocel.

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Natural Herbal Remedy Wumei Decoction Ameliorates Intestinal Mucosal Inflammation by Inhibiting Th1/Th17 Cell Differentiation and Maintaining Microbial Homeostasis.

WMD ameliorates chronic colitis in mice induced by DSS or reconstituted with CD45RBhighCD4+ T cells through suppressing Th1/Th17 cell differentiation and the secretion of proinflammatory cytokines, maintaining epithelial barrier function, and improving the dysbiosis.

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The Neglected Gut Microbiome: Fungi, Protozoa, and Bacteriophages in Inflammatory Bowel Disease.

Further, we highlight the importance of studying nonbacterial microorganisms alongside bacteria for a comprehensive view of the whole IBD biome and to provide a more precise definition of dysbiosis in patients. With the rise in popularity of microbiome-altering therapies for the treatment of IBD, such as fecal microbiota transplantation, it is important that we address these knowledge gaps to ensure safe and effective treatment of patients.

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WITHDRAWN: EFFICACY, SAFETY, AND TOLERABILITY OF OMILANCOR IN A PHASE 2 RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF PATIENTS WITH ULCERATIVE COLITIS.

Once a day oral dosing with omilancor was well-tolerated and induced clinical remission in a Phase II mild to moderate UC population. A Phase II study in CD and a Phase III program in UC (PACIFY) were initiated in 2021 and are currently recruiting.

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J Crohns Colitis

Management and long-term outcomes of Crohn's disease complicated with enterocutaneous fistula: ECUFIT study from GETECCU.

ECF complicating CD are rare but entail a high burden of medical and surgical resources. Closure rates are high, usually after surgery, and fistula recurrence is uncommon. A significant proportion of patients receiving medical therapy can achieve fistula closure.

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Mesenteric adipocyte contributes to intestinal fibrosis in Crohn's disease through the ATX-LPA axis.

The ATX-LPA axis regulated intestinal fibrosis by influencing the proliferation and differentiation of intestinal fibroblasts. Inhibiting this axis may be a therapeutic target for intestinal fibrosis in CD.

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Smoking behavior changes after diagnosis of inflammatory bowel disease and risk of all-cause mortality.

In three cohorts of health professionals, a substantial proportion of patients with new diagnosis of CD and UC and history of smoking continued to smoke post-diagnosis. Smoking cessation around the time of diagnosis was associated with a significant reduction in mortality.

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J Hepatol

COMMD10 inhibits HIF1a/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma.

COMMD10 inhibits HIF1a/CP loop to enhance ferroptosis and radiosensitivity via disrupting Cu-Fe homeostasis in HCC. This work provides new targets and treatment strategies for HCC radioresistance.

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Complexity of ballooned hepatocyte feature recognition: Defining a training atlas for artificial intelligence-based imaging in NAFLD.

The substantial divergence in hepatocyte ballooning identified amongst expert hepato-pathologists suggests that ballooning is a spectrum, too subjective for its presence or complete absence to be unequivocally determined as a trial endpoint. A concordance atlas may be used to train AI assistive technologies to reproducibly quantify ballooned hepatocytes that standardise assessment of therapeutic efficacy. This atlas serves as a reference-standard for ongoing work to refine how ballooning is classified by both pathologists and AI.

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Predicted estimates of resting energy expenditure have limited clinical utility in patients with cirrhosis.

Prediction equations do not provide useful estimates of REE in patients with cirrhosis. REE should be directly measured.

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Probability of HBsAg loss after nucleo(s)tide analogue withdrawal depends on HBV genotype and viral antigen levels.

The probability of HBsAg loss after NUC cessation varies according to patient ethnicity, HBV genotype and end-of-treatment viral antigen levels. Patients with low HBsAg (<100 IU/ml) and/or undetectable HBcrAg levels, particularly if non-Asian or infected with HBV genotype C, appear to be the best candidates for therapy withdrawal.

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Liver Transpl

Cerium oxide nanoparticles administration during machine perfusion of discarded human livers: a pilot study.

Alb-NC during ex situ perfusion decreased oxidative stress, up-regulating graft antioxidant defense. They could be a tool to improve quality graft during NMP and represent an antioxidant strategy aimed at protecting the graft against reperfusion injury during liver transplantation.

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Intraoperative Risk Factors of Acute Kidney Injury Following Liver Transplantation.

Our study identified significant association between several potentially modifiable variables with post transplant AKI. The addition of intraoperative data did not improve overall model discrimination.

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Portal Vein Complications and Outcomes Following Pediatric Liver Transplant: Data from the Society of Pediatric Liver Transplantation.

Our results recognize the common occurrence of PVC following pediatric liver transplant, describe independently associated risk factors, and determine that patients with PVC have worse outcomes. Further studies are needed to improve PVC prevention, detection and management strategies.

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Neurogastroenterol Motil

Gastrointestinal motility disorders in patients with multiple sclerosis: A single-center study.

In addition to slow colonic transit and anorectal dysfunction leading to constipation in MS, 22% of patients had accelerated gastric emptying.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther

Editorial: concurrent fatty liver and chronic viral hepatitis: a dual calamity leading to increased risk of hepatocellular carcinoma?

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Editorial: global liver fat accumulation and global health-towards a sustainable development goal.

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Editorial: safety of ustekinumab in pregnancy-are we there yet?

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Editorial: targeting aberrant hepatic inflammation for treatment of non-alcoholic steatohepatitis.

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Editorial: time to eat? Skipping breakfast in metabolic-associated fatty liver disease.

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Gastroenterology

Editorial Commentary for the manuscript entitled "Docking protein p130Cas regulates acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis" A p130Cas-mediated mechanism governs acinar to ductal metaplasia and the initiation of pancreatic ductal adenocarcinoma.

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Gut

Gut microbiome and health: mechanistic insights.

We examine well-established metabolites (ie, short-chain fatty acids, bile acids, trimethylamine N-oxide) and extend this to more recently identified molecular actors (ie, endocannabinoids, bioactive lipids, phenolic-derived compounds, advanced glycation end products and enterosynes) and their specific receptors such as peroxisome proliferator-activated receptor alpha (PPARa) and gamma (PPAR), aryl hydrocarbon receptor (AhR), and G protein-coupled receptors (ie, GPR41, GPR43, GPR119, Takeda G protein-coupled receptor 5). Altogether, understanding the complexity and the molecular aspects linking gut microbes to health will help to set the basis for novel therapies that are already being developed.

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Hepatology

Healthy Peribiliary Glands are Necessary for Successful Liver Transplantation.

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Improving the Fitness of the NASH Clinical Trial: Standardizing the Standard of Care Intervention.

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Microwave ablation in skilled hands. A treatment opportunity gaining room in the field of single HCC 3-5 cm.

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Viral integrations in chronic Hepatitis B infection: purposeless passenger or problematic promoter of persistence?

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Liver Transpl

Blood Pressure Variability in Liver Transplant Recipients: The Who, What, When, and How.

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Integrating Specialist Palliative Care in the Liver Transplant Evaluation Process: Creating An MDT Greater than the Sum of its Parts?

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Mending the MELD: An in-depth review of the past, present, and future portopulmonary hypertension MELD exception.

Thus, in February 2021, the Organ Procurement Transplantation Network (OPTN) approved proposed modifications to POPH MELD exception criteria, now allowing either of the following post-treatment, pre-LT hemodynamic profiles: mPAP less than 35 mmHg and post-treatment PVR less than 400 dynes*sec/cm5 (or less than 5 WU) or mPAP greater than or equal to 35 mmHg and less than 45 mmHg and post-treatment PVR less than 240 dynes*sec/cm5 (or less than 3 WU). This article reviews the history of the POPH MELD exception, describes the recent modifications to the exception criteria and the evidence supporting them, and also highlights unanswered questions and areas for future research.

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No Salvation Without Regeneration.

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Surveillance Biopsies in Pediatric Liver Transplantation: Is the Juice Worth the Squeeze?

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When the sun sets, who doth not look for night?

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Will this liver work? The "ibis redibis" of machine preservation viability assessment.

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

Editorial: concurrent fatty liver and chronic viral hepatitis: a dual calamity leading to increased risk of hepatocellular carcinoma? Authors' reply.

Pubmed   Journal   ReadQx 

Editorial: global liver fat accumulation and global health-towards a sustainable development goal. Authors' reply.

Pubmed   Journal   ReadQx 

Editorial: targeting aberrant hepatic inflammation for treatment of non-alcoholic steatohepatitis-authors' reply.

Pubmed   Journal   ReadQx 

Editorial: time to eat? Skipping breakfast in metabolic-associated fatty liver disease-Authors' reply.

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Letter: combination of common and novel rare NUDT15 variants should also be considered-authors' reply.

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Letter: combination of common and novel rare NUDT15 variants should also be considered.

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Letter: loss of response to anti-TNFa agents depends on treatment duration in patients with inflammatory bowel disease-authors' reply.

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Letter: loss of response to anti-TNFa agents in patients with inflammatory bowel disease depends on treatment duration.

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Letter: towards gender-stratified colorectal cancer screening and surveillance?

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Letter: towards gender-stratified colorectal cancer screening and surveillance? Authors' reply.

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Letter: treatment with subcutaneous CT-P13 in Crohn's disease patients with intravenous infliximab failure.

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Gut

High antibody response in relation to immunosuppressive blood levels in liver transplant recipients after SARS-CoV-2 vaccination: an observational, cohort study.

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Hepatology

Letter to the editor: Both universal screening and vaccination are essential components of a multipronged approach to hepatitis B elimination.

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Letter to the Editor: In patients with established NASH cirrhosis, is there no role of weight reduction in reversing fibrosis?

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Letter to the Editor: is PAI-1 a thrombotic biomarker in NASH cirrhosis?

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Letter to the Editor: Is TIPS the best treatment for non-cirrhotic adults with EPHVO and portal hypertension?

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Letter to the Editor: Selection of Appropriate Statistical Methods for Prediction Model.

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Leveraging universal adult vaccination as part of a multipronged approach to eliminate hepatitis B in the US.

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Prediction of Biochemical Nonresolution in Patients with Chronic Drug-induced Liver Injury: A Large Multicenter Study.

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Reply to "prospective study of stereotactic body radiation therapy for hepatocellular carcinoma on waitlist for liver transplant".

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Reply to: Selection of Appropriate Statistical Methods for Prediction Model.

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Response to Letter to the Editor: Prediction of Biochemical Nonresolution in Patients with Chronic Drug-induced Liver Injury: A Large Multicenter Study.

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Spontaneous regression of cirrhosis: a paradigm shift in our understanding of the natural history of non-alcoholic steatohepatitis (NASH).

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J Hepatol

Gut liver muscle brain axis: a comprehensive viewpoint on prognosis in cirrhosis.

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Receptor Tyrosine kinase co-amplification and benefit from HER2 inhibitors in Biliary Tract Cancers.

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Liver Transpl

LT-21-896 - Response to the Letter to the Editor by Yang and colleagues.

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Preliminary evaluation of atelizumab and bevacizumab as salvage treatment for recurrent hepatocellular carcinoma after liver transplantation.

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Shared and Data-Driven Decision-Making with Transplant Recipients about COVID-19 Vaccination is Crucial.

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Neurogastroenterol Motil

Letter in response to Black et al. (2020).

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Others

all remaining publications eg case reports, images of the month, etc…

Am J Gastroenterol

A Pragmatic Approach to the Evaluation and Treatment of Abdominal Bloating and Distension.

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Chronic hepatitis B and fatty liver -weal or woe?

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Correction to: Paraneoplastic Achalasia Associated With Neuroendocrine Tumor.

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Endoscopic R1 / Rx resection of T1 colorectal cancer - What next?

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May-Thurner syndrome in a patient with ulcerative colitis complicated by coronavirus disease 2019.

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Endoscopy

Avoiding a plane crash with colonoscopy.

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Endoscopic full-thickness resection for T1 colorectal cancer: here to stay!

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Searching for a better mousetrap for ablation of Barrett's esophagus.

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Gastrointest Endosc

Downhill esophageal varices in a patient with recurrent hemodialysis permacath thrombosis.

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Endoscopic diagnosis of Santoriniceles with reverse pancreas divisum.

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How to manage appendicitis in early pregnancy better.

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Rare case of small bowel foreign body in peritoneal dialysis.

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Hepatology

AASLD Practice Guidance: Palliative care and symptom-based management in decompensated cirrhosis.

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Inflamm Bowel Dis

An Unusual Case of Hypernatremia in Patient With Ulcerative Colitis.

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